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The Best Dermal Fillers of 2021

The Best Dermal Fillers of 2021

In 2020, there have been conducted around 3 million of dermal fillers injections worldwide. It proves the growing popularity of non-invasive rejuvenation, facelift, and contouring with the help of hyaluronic acid injectable treatments. Feeling the increased demand of the cosmetology market in liquid injectables, the manufacturers offer dozens of brands and new fillers t restore the youthful appearance, shape and reshape facial contours, fight aesthetic imperfections, and satisfy the tastes of the most capricious patients.

Want to know what dermal gels brands men and women chose in 2021 the most? Keep on reading and find out why the following products conquered the hearts of doctors and patients.

What Are the Best Injectable Dermal Fillers on the Market?


Juvederm facial fillers with hyaluronic acid for a few years in a row continue being the leaders in the sphere of injectable cosmetology. Their universal line Ultra represented by Juvederm Ultra 2, Ultra 3, Ultra 4, Ultra Smile, Ultra XC, and Ultra Plus XC are one of the most best-selling injectables in the world.

However, the brand does not stop designing and improving its products to smooth wrinkles, restore volume of the fading dermis, plump lips, and meet the demand for new trends in the field of aesthetic medicine. Đ•his is how the world saw an innovative gel for contour plastics, defining the jawline, and a chin augmentation – Juvederm Volux – the densest filler in the family of liquid injectables that will help to obtain cheekbones of Angelina Jolie and clear, defined facial oval.

Impeccable quality, excellent results, and a wide range of fillers for various skin types, facial areas, able to solve any imperfections make Juvederm among the most popular brands year after year, and many predict its popularity in the next years. But who knows, maybe some manufacturer will surprise us and release indeed revolutionary filler that will beat Juvederm!


Revolax is a new brand of dermal fillers from the Korean manufacturer Fox Group International Company. Although it has been introduced to the European and American market just in 2017, for a few years it managed to become of the best brands of wrinkle fillers and patients’ choice in 2021.

The brand cannot boast a wide spectrum of products. At the moment it has only 3 products: Revolux Fine, Revolux Deep, and Revolux Sub-Q, but their excellent quality, satisfactory results, and extremely affordable price helped the brand to gain super popularity in 2021 and stand on par with such giants like Juvederm and Restylane.


Profhilo is an innovative injectable treatment for rejuvenation, relaunching inner collagen and elastin production processes, smoothing wrinkles, and restoring natural-looking volume. At present time, Profhilo is one of the highly concentrated fillers with hyaluronic acid. The manufacturer uses a unique technology of extreme heating and rapid cooling of 2 types of HA, causing the formation of hydrogen bonds, which remain inseparable in the skin tissues and allow maintaining a high concentration of acid.


Dermal fillers Saypha from the Chroma manufacturer also are among the best fillers this year. Hyaluronic acid gels for smoothing facial wrinkles, restoring volume loss, and obtaining pillowy lips and full cheeks produce more than 50 million prefilled syringes per year.

How can you explain such crazy popularity of the filler? There may be various suggestions, but Saypha is among the most budgetary alternatives to the more expensive brands like Juvederm and Restylane. For you to understand, the price for the pack of Saypha is 3-5 times lower than, for example, for Juvederm.

At the same time, the fillers are of high quality and provide beautiful and natural results in patients of various ages.

That is why many patients who are seeking a beneficial price-quality ratio, choose Saypha for skin smoothness.


Stylage is another brand of hyaluronic acid fillers that is present on the market since 2009. The peculiarity of these dermal products is that except for non-organic HA, they contain mannitol that is a natural antioxidant to fight free radicals and slow down the destruction of natural hyaluronic acid in the dermal cells.

The brand is represented by the following preparations: Stylage S, Stylage M, Stylage L, Stylage XL, Stylage Special Lips, Stylage Hydro, Stylage Hydromax. They are available with and without the local anesthetic lidocaine.

Filler S possesses the lightest density level of the gel making them suitable for fragile and sensitive skin correction like smile lines and horizontal lip lines, crow’s feet, and other lines in the perioral area. M, L are denser filler, and Xl is a super dense filler for the volumetric correction of the facial features like cheeks, chin, and jawline.

The presence of mannitol makes Stylage filers unique in their kind that fight aging changes not just by replenishing the lost volume in the tissues from inside but preventing premature aging and slowing down the natural aging by blocking the free radicals that have an incredibly negative impact on the dermal matrix.


Restylane from the Swizz manufacturer Galderma is perhaps the main competitor to Juvederm on the cosmetic market. It is one of not so many brands that has elaborated a wide range of products: Restylane, Restylane Kysse, Restylane Volyme, Restylane Lyft, Restylane Refyne, Restylane Defyne, Restylane Lyps, Restylane SUBQ.

The manufacturer has also elaborated on 2 unique patented technologies (NASHA and OBT) for the cross-linking of hyaluronic acid and obtaining unique sterile gels with various levels of density and viscosity for filling in big volume deficiencies and the tinies shallow areas in the dermis, eliminating fine lines under the eyes and deep nasolabial folds, restoring the natural shape of the face or sculpting cheekbones and jawline.

The long-lasting correction after the skin treatment with Restylane products (9-18 months) with such an impressive range of dermal injectables ensured the popularity on the market for 2021 and supposedly a few following years.

The Bottom Line

These were top dermal filler brands in 2021, proven by time and the choices of millions of satisfied patients and qualified specialists all over the globe. Juvederm, Revolax, Profhilo, Saypha, Stylage, and Restylane are the undeniable leaders today, and who knows, maybe for the following few seasons or years.

Some of the brands are more expensive, others are more budgetary. They definitely have their benefits, and everyone can choose the products that suit the needs and budget.

For you to know, a great variety of the products from the mentioned brands are available for purchase on our website Contact our sales managers, and they will provide you with more detailed information.

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